Name & Description
The medicine is called Temozolamide 20 mg. It is manufactured by Cadila and belongs to the Uncategorised category. Each strip contains 5 capsules. The actual MRP of the medicine is Rs. 2025.1, but it is currently available at a discounted price of Rs. 728, offering a discount of 64.05%.
Active Ingredients
Temozolamide contains the active ingredient Temozolomide, which is an alkylating agent used in the treatment of certain types of brain tumors.
Pharmacological Properties
Temozolomide works by interfering with the DNA replication process of cancer cells, leading to their destruction. It is well absorbed after oral administration and penetrates the blood-brain barrier effectively.
Indications
Temozolamide is indicated for the treatment of specific brain tumors, including glioblastoma multiforme and anaplastic astrocytoma, either alone or in combination with other chemotherapy drugs and radiation therapy.
Contraindications
Temozolamide is contraindicated in patients with a history of hypersensitivity to the drug or its components. It should not be used in pregnant women or patients with severe bone marrow suppression.
Dosage
The dosage of Temozolamide is individualized based on the patient’s condition, weight, and other factors. It is typically taken orally once daily for a specific treatment cycle as prescribed by the healthcare provider.
Side Effects
Common side effects of Temozolamide include nausea, vomiting, fatigue, headaches, loss of appetite, and hair loss. Serious side effects may include bone marrow suppression, liver toxicity, and an increased risk of infections.
Drug Interactions
Temozolamide may interact with certain medications, such as anticonvulsants, dexamethasone, and blood thinners, affecting their efficacy or increasing the risk of side effects. It is essential to inform the healthcare provider about all the medications being taken before starting Temozolamide.
Patient Counseling
Patients taking Temozolamide should be advised to follow the prescribed dosage schedule carefully and report any unusual symptoms or side effects to their healthcare provider promptly. They should also be informed about the potential risks and benefits of the treatment.
Clinical Evidence
Temozolamide has been extensively studied in clinical trials for its efficacy in treating various brain tumors. The results have shown significant improvements in overall survival rates and progression-free survival, especially when used in combination with other treatment modalities.
Frequently Asked Questions (FAQs)
1. What should I do if I miss a dose of Temozolamide?
If you miss a dose of Temozolamide, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
2. Can Temozolamide be taken with food?
Temozolamide can be taken with or without food. However, some patients may experience less nausea and stomach upset if they take it with food. Follow your healthcare provider’s recommendations regarding food intake while taking Temozolamide.
3. Are there any specific monitoring requirements while on Temozolamide treatment?
Patients receiving Temozolamide therapy may require regular monitoring of their blood cell counts, liver function tests, and overall health status. Your healthcare provider will advise you on the specific monitoring schedule based on your individual needs.
4. Can Temozolamide cause infertility or affect fertility in men and women?
Temozolamide has the potential to cause temporary or permanent infertility, especially in men. Women of childbearing age should use effective contraceptive measures during and after treatment with Temozolamide to prevent pregnancy. Discuss fertility concerns with your healthcare provider before starting treatment.
5. Is it safe to drive or operate machinery while taking Temozolamide?
Temozolamide may cause dizziness, drowsiness, or other neurological side effects that can impair your ability to drive or operate machinery safely. It is recommended to avoid such activities if you experience these side effects while taking Temozolamide.
6. Can Temozolamide be used in elderly patients?
Temozolamide can be used in elderly patients, but the dosage may need to be adjusted based on age-related changes in organ function and overall health status. Your healthcare provider will determine the appropriate dose and treatment plan for elderly patients.
7. What should I do in case of an overdose of Temozolamide?
If you suspect an overdose of Temozolamide, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe nausea, vomiting, seizures, and impaired consciousness. Do not attempt to self-manage an overdose situation.
By following the information provided here, patients can better understand Temozolamide, its uses, potential side effects, and important considerations while undergoing treatment. It is essential to consult a healthcare provider for personalized guidance and monitoring throughout the course of Temozolamide therapy.
