Medicine Information: SITAGLIPTIN 100 MG + DAPAGLIFLOZIN 10 MG
Sitagliptin 100 mg + Dapagliflozin 10 mg is a combination medication used in the management of type 2 diabetes mellitus. It is manufactured by Mascot Health Series and falls under the category of uncategorised medicines. Each pack contains a strip of 10 tablets. The actual Maximum Retail Price (MRP) of this medicine is Rs. 317, but it is currently available at a discounted price of Rs. 160, offering a discount of 49.53%.
Active Ingredients:
Sitagliptin and dapagliflozin are the active ingredients in this medication. Sitagliptin belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which work by increasing the levels of incretin hormones in the body. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that helps lower blood sugar levels by causing the kidneys to remove glucose through urine.
Pharmacological Properties:
Sitagliptin and dapagliflozin work through different mechanisms to help regulate blood sugar levels in patients with type 2 diabetes. By inhibiting DPP-4 enzyme, sitagliptin enhances the action of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), leading to increased insulin secretion and decreased glucagon release. On the other hand, dapagliflozin blocks the reabsorption of glucose by the kidneys, promoting its excretion in urine and lowering blood glucose levels.
Indications:
Sitagliptin 100 mg + Dapagliflozin 10 mg is indicated for the treatment of type 2 diabetes mellitus in adults who require additional blood sugar control alongside diet and exercise. It is not intended for the treatment of type 1 diabetes or diabetic ketoacidosis.
Contraindications:
This medication is contraindicated in patients with a known hypersensitivity to sitagliptin, dapagliflozin, or any other components of the formulation. It should not be used in individuals with severe renal impairment, end-stage renal disease, or history of ketoacidosis.
Dosage:
The usual recommended dose of Sitagliptin 100 mg + Dapagliflozin 10 mg is one tablet taken once daily with or without food. The dosage may vary depending on individual patient needs and response to treatment. It is important to follow the prescribed regimen and not exceed the recommended dose.
Side Effects:
Common side effects associated with Sitagliptin 100 mg + Dapagliflozin 10 mg may include:
– Hypoglycemia (low blood sugar)
– Urinary tract infections
– Increased urination
– Nasopharyngitis (inflammation of the throat and nasal passages)
More severe side effects may include:
– Pancreatitis
– Hypersensitivity reactions
– Acute kidney injury
– Severe urinary tract infections
It is essential to report any unusual or persistent side effects to a healthcare provider promptly.
Drug Interactions:
Sitagliptin 100 mg + Dapagliflozin 10 mg may interact with certain medications, including but not limited to:
– Diuretics
– Insulin or sulfonylureas
– Corticosteroids
– Antifungal agents
– ACE inhibitors
Patients should inform their healthcare provider about all prescription, over-the-counter, and herbal supplements they are taking to avoid potential drug interactions.
Patient Counseling:
Before starting treatment with Sitagliptin 100 mg + Dapagliflozin 10 mg, patients should be counseled on the following:
– The importance of adherence to the prescribed dosage and schedule
– Monitoring blood sugar levels regularly as directed
– Signs and symptoms of hypoglycemia and hyperglycemia
– Proper diet and exercise regimen to complement medication therapy
Patients should also be advised to seek medical help if they experience any unusual symptoms or side effects while taking this medication.
Clinical Evidence:
Clinical studies have demonstrated the efficacy and safety of Sitagliptin 100 mg + Dapagliflozin 10 mg in the management of type 2 diabetes mellitus. These studies have shown improvements in glycemic control, reduction in HbA1c levels, and favorable effects on cardiovascular outcomes in certain patient populations. Long-term data also supports the use of this combination therapy in maintaining blood sugar levels within target ranges.
Frequently Asked Questions (FAQs):
1. How should I take Sitagliptin 100 mg + Dapagliflozin 10 mg?
The usual dose is one tablet daily with or without food. Follow the instructions provided by your healthcare provider.
2. What are the common side effects of this medication?
Common side effects may include hypoglycemia, urinary tract infections, increased urination, and nasopharyngitis.
3. Can I use this medicine if I have kidney problems?
Patients with severe renal impairment or end-stage renal disease should not use this medication.
4. Are there any drug interactions I should be aware of?
Inform your healthcare provider about all medications you are taking, including diuretics, insulin, antifungal agents, and corticosteroids.
5. How long does it take for Sitagliptin 100 mg + Dapagliflozin 10 mg to start working?
The onset of action may vary, but you should follow up with your healthcare provider to assess the effectiveness of the treatment.
This comprehensive information should provide a detailed overview of Sitagliptin 100 mg + Dapagliflozin 10 mg and its use in managing type 2 diabetes mellitus. If you have any further questions or concerns, consult your healthcare provider for personalized advice.
