SACUBITRIL + VALSARTAN: Active Ingredients and Pharmacological Properties
SACUBITRIL 49 MG + VALSARTAN 51 MG is a combination medication that contains two active ingredients – sacubitril and valsartan. Sacubitril is a neprilysin inhibitor, while valsartan is an angiotensin II receptor blocker (ARB). This combination acts by increasing the levels of natriuretic peptides and inhibiting the renin-angiotensin-aldosterone system, resulting in vasodilation and improved cardiac function.
Indications
SACUBITRIL + VALSARTAN is indicated for the treatment of heart failure with reduced ejection fraction (HFrEF) in adult patients who are symptomatic despite optimal medical therapy. It is also used to reduce the risk of cardiovascular death and hospitalization for heart failure in these patients.
Contraindications
SACUBITRIL + VALSARTAN should not be used in patients who have a history of angioedema related to previous ACE inhibitor or ARB therapy. It is contraindicated in patients with a history of hereditary or idiopathic angioedema. Pregnant women should also avoid using this medication.
Dosage
The recommended starting dose of SACUBITRIL + VALSARTAN is usually one tablet once daily. The dosage may be adjusted by the healthcare provider based on the individual patient’s condition and response to treatment.
Side Effects
Common side effects of SACUBITRIL + VALSARTAN may include hypotension (low blood pressure), dizziness, hyperkalemia (high levels of potassium in the blood), cough, and renal impairment. Patients should contact their healthcare provider if they experience any severe or persistent side effects.
Drug Interactions
SACUBITRIL + VALSARTAN may interact with other medications such as potassium-sparing diuretics, potassium supplements, and nonsteroidal anti-inflammatory drugs (NSAIDs). It is important to inform the healthcare provider about all medications, supplements, and herbal products being taken before starting this treatment.
Patient Counseling
Patients should be counseled on the importance of adhering to the prescribed dosage and schedule of SACUBITRIL + VALSARTAN. They should also be advised to report any unusual symptoms or side effects to their healthcare provider promptly. Additionally, patients should be informed about the potential risks and benefits of this medication.
Clinical Evidence
Clinical studies have demonstrated the efficacy of SACUBITRIL + VALSARTAN in reducing the risk of cardiovascular death and hospitalization for heart failure in patients with HFrEF. These studies have shown significant improvements in outcomes compared to standard therapy alone.
Frequently Asked Questions (FAQs)
Q: How should I take SACUBITRIL + VALSARTAN?
A: SACUBITRIL + VALSARTAN is usually taken once daily with or without food as directed by your healthcare provider.
Q: What should I do if I miss a dose of SACUBITRIL + VALSARTAN?
A: If you miss a dose of SACUBITRIL + VALSARTAN, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Q: Can SACUBITRIL + VALSARTAN be used during pregnancy?
A: SACUBITRIL + VALSARTAN is not recommended for use during pregnancy due to potential risks to the fetus. Pregnant women should consult their healthcare provider for alternative treatment options.
Q: What should I do in case of an overdose of SACUBITRIL + VALSARTAN?
A: In case of an overdose of SACUBITRIL + VALSARTAN, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing.
Q: Can I drink alcohol while taking SACUBITRIL + VALSARTAN?
A: It is generally recommended to limit or avoid alcohol consumption while taking SACUBITRIL + VALSARTAN, as alcohol may exacerbate certain side effects of the medication.
Q: How long does it take for SACUBITRIL + VALSARTAN to start working?
A: The effects of SACUBITRIL + VALSARTAN may vary from one individual to another. Some patients may experience improvement in symptoms within a few weeks, while others may take longer. It is important to continue taking the medication as prescribed by your healthcare provider.
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