PREGABALIN 75 MG + DULOXETINE 20 MG

PREGABALIN 75 MG + DULOXETINE 20 MG – Overview

The medicine, PREGABALIN 75 MG + DULOXETINE 20 MG, is a combination drug manufactured by MASCOT HEALTH SERIES. It falls under the category of Uncategorised medicines and is available in a strip packing type containing 10 capsules. The actual MRP of the medicine is Rs. 265, but it is currently being offered at a discounted price of Rs. 80, providing a discount of 69.81%.

Active Ingredients

PREGABALIN 75 MG + DULOXETINE 20 MG comprises two active ingredients: pregabalin and duloxetine. Pregabalin is an anticonvulsant that is also used to treat nerve pain and fibromyalgia. Duloxetine, on the other hand, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression, anxiety, and certain types of chronic pain conditions.

Pharmacological Properties

The combination of pregabalin and duloxetine offers a synergistic effect in managing various conditions. Pregabalin exerts its effects by binding to calcium channels in the central nervous system, thereby modulating the release of neurotransmitters involved in pain signaling. Duloxetine, on the other hand, works by increasing the levels of serotonin and norepinephrine in the brain, which helps to improve mood and reduce pain perception.

Indications

PREGABALIN 75 MG + DULOXETINE 20 MG is indicated for the treatment of various conditions, including:
– Neuropathic pain
– Fibromyalgia
– Generalized anxiety disorder
– Major depressive disorder
– Chronic musculoskeletal pain

Contraindications

It is important to note that this medicine is contraindicated in certain situations. Contraindications for PREGABALIN 75 MG + DULOXETINE 20 MG include:
– Hypersensitivity to pregabalin, duloxetine, or any other component of the formulation
– Monoamine oxidase inhibitor (MAOI) use within the past 14 days
– Severe renal impairment
– Uncontrolled narrow-angle glaucoma

Dosage

The dosage of PREGABALIN 75 MG + DULOXETINE 20 MG should be individualized based on the patient’s condition and response to treatment. It is typically recommended to start with a low dose and titrate gradually to achieve the desired therapeutic effect while minimizing side effects. Patients should follow the prescribed dosing schedule provided by their healthcare provider.

Side Effects

Like all medications, PREGABALIN 75 MG + DULOXETINE 20 MG can cause side effects. Common side effects may include:
– Nausea
– Drowsiness
– Dizziness
– Dry mouth
– Constipation
– Headache
– Fatigue

Some more serious side effects may include:
– Suicidal thoughts or behavior
– Serotonin syndrome
– Liver damage
– Allergic reactions

Patients should seek medical attention if they experience any severe or persistent side effects while taking this medication.

Drug Interactions

PREGABALIN 75 MG + DULOXETINE 20 MG may interact with other medications, supplements, or substances. It is important to inform your healthcare provider about all the medications you are taking to prevent potential drug interactions. Some common drug interactions include:
– MAOIs and other serotonergic drugs
– Other medications that affect serotonin levels
– Antiepileptic drugs
– CNS depressants

Patient Counseling

Patients taking PREGABALIN 75 MG + DULOXETINE 20 MG should be counseled on the following points:
– Take the medication as directed by your healthcare provider
– Report any unusual or severe side effects to your healthcare provider
– Avoid alcohol consumption while taking this medication
– Inform your healthcare provider about all the medications you are currently taking
– Do not stop the medication abruptly without consulting your healthcare provider

Clinical Evidence

Several clinical studies have demonstrated the efficacy and safety of PREGABALIN 75 MG + DULOXETINE 20 MG in the management of neuropathic pain, fibromyalgia, and psychiatric disorders. These studies have shown that the combination of pregabalin and duloxetine provides better outcomes compared to individual monotherapy in certain patient populations.