Overview of Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg
Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg is a combination medicine formulated to provide relief from symptoms associated with allergies, common cold, and flu. This medication is manufactured by Roussel and is available in a strip pack of 10 tablets. The medicine is a blend of three active ingredients – Paracetamol, Phenylephrine HCl, and Chlorpheniramine Maleate, each playing a unique role in alleviating different symptoms.
Active Ingredients
1. Paracetamol 325mg: Paracetamol, also known as acetaminophen, is a widely used analgesic (pain reliever) and antipyretic (fever reducer). It works by inhibiting the production of certain chemicals in the brain that cause pain and fever.
2. Phenylephrine HCl 5mg: Phenylephrine is a decongestant that works by narrowing the blood vessels in the nasal passages, leading to reduced congestion and improved breathing.
3. Chlorpheniramine Maleate 4mg: Chlorpheniramine is an antihistamine that helps relieve symptoms of allergies such as sneezing, itching, watery eyes, and runny nose by blocking the action of histamine in the body.
Pharmacological Properties
The combination of Paracetamol, Phenylephrine HCl, and Chlorpheniramine Maleate targets multiple symptoms commonly experienced during cold and flu. Paracetamol provides pain relief and reduces fever, while Phenylephrine HCl acts as a decongestant to relieve nasal congestion. Chlorpheniramine Maleate helps control allergy symptoms by blocking the effects of histamine.
Indications
Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg is indicated for the relief of symptoms associated with the common cold, flu, allergies, sinus congestion, headache, body aches, fever, and sneezing.
Contraindications
This medication is contraindicated in individuals with a known hypersensitivity to any of its components, severe heart disease, severe hypertension, hyperthyroidism, severe kidney disease, and closed-angle glaucoma. It should not be used in patients receiving monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping such treatment.
Dosage
The recommended dosage of Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg for adults and children over 12 years of age is one tablet every 4 to 6 hours as needed, not exceeding 4 tablets in 24 hours. Children below 12 years should consult a healthcare provider for appropriate dosing guidance.
Side Effects
Some common side effects of this medication include dizziness, drowsiness, dry mouth, nausea, vomiting, blurred vision, and constipation. These side effects are usually mild and temporary. However, if you experience severe or persistent side effects, seek medical attention promptly.
Drug Interactions
Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg may interact with certain medications, such as MAOIs, beta-blockers, tricyclic antidepressants, and other decongestants or antihistamines. Inform your healthcare provider about all the medicines you are currently taking to avoid potential drug interactions.
Patient Counseling
Before using this medication, inform your healthcare provider about any existing medical conditions, allergies, or medications you are using. Follow the recommended dosage instructions and avoid exceeding the maximum daily dose. Drink an adequate amount of fluids to prevent dehydration while taking this medication. If symptoms persist or worsen, contact your healthcare provider.
Clinical Evidence
Clinical studies have demonstrated the efficacy and safety of Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg in providing relief from cold and flu symptoms. The combination of active ingredients in this medication has been shown to effectively alleviate nasal congestion, headache, fever, and other symptoms associated with respiratory infections.
Frequently Asked Questions (FAQs)
1. Can I take this medication if I have high blood pressure?
Answer: Patients with severe hypertension should avoid taking this medication as it contains Phenylephrine, which can potentially elevate blood pressure.
2. Is it safe to drive or operate machinery while taking this medicine?
Answer: This medication may cause dizziness or drowsiness in some individuals. It is advisable to avoid driving or operating heavy machinery until you know how the medicine affects you.
3. How quickly does this medication start to work?
Answer: The onset of action of Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg varies but you may start to feel relief within 30 minutes to an hour after taking the medicine.
4. Can I take this medicine if I am pregnant or breastfeeding?
Answer: Pregnant or breastfeeding women should consult a healthcare provider before using this medication to assess the potential risks and benefits.
5. What should I do if I accidentally take more than the recommended dose?
Answer: In case of an overdose, seek immediate medical attention or contact a poison control center. Overdose can lead to serious complications, including liver damage and increased heart rate.
In conclusion, Paracetamol 325mg + Phenylephrine HCl 5mg + Chlorpheniramine Maleate 4mg is a well-rounded medication for managing cold, flu, and allergy symptoms. It is essential to follow the prescribed dosage, be aware of potential side effects and drug interactions, and seek medical advice if needed. If you have any further questions or concerns about this medication, consult your healthcare provider for personalized guidance.
