Name & Description:
NINTEDANIB 150 MG
Manufacturer:
Manufacturer: CLEVUS LIFESCIENCES
Medicine Category:
Uncategorised
Packing Type:
STRIP of 10CAP
Medicine Pricing:
ACTUAL MRP: Rs. 900
Discounted Price: Rs. 830
Discount Percentage: 7.78%
Active Ingredients:
Nintedanib
Pharmacological Properties:
Nintedanib is a tyrosine kinase inhibitor characterized by its anti-inflammatory and anti-fibrotic actions. It targets multiple tyrosine kinases involved in the pathogenesis of fibrotic disorders, inhibiting their activity and reducing fibroblast proliferation and collagen synthesis.
Indications:
Nintedanib is indicated for the treatment of idiopathic pulmonary fibrosis (IPF) to slow down the decline in lung function.
Contraindications:
Nintedanib is contraindicated in patients with a history of hypersensitivity to the active substance or any of the excipients, severe hepatic impairment, pregnancy, and breastfeeding.
Dosage:
The recommended dosage of nintedanib is 150 mg twice daily, preferably with food to reduce gastrointestinal side effects.
Side Effects:
Common side effects of nintedanib may include diarrhea, nausea, abdominal pain, vomiting, decreased appetite, liver enzyme elevation, fatigue, and weight loss.
Drug Interactions:
Nintedanib may interact with strong CYP3A4 inducers or inhibitors, increasing or decreasing its plasma concentration. It is advised to avoid concomitant use with these substances.
Patient Counseling:
Patients should be counseled on the importance of adherence to the prescribed dosage regimen, potential side effects such as gastrointestinal symptoms, and the need for regular monitoring of liver function tests during treatment with nintedanib.
Clinical Evidence:
Clinical trials have demonstrated the efficacy of nintedanib in reducing the decline in lung function and improving progression-free survival in patients with idiopathic pulmonary fibrosis.
Frequently Asked Questions:
1. What is Nintedanib used for?
Nintedanib is used for the treatment of idiopathic pulmonary fibrosis (IPF) to slow down the decline in lung function.
2. What are the common side effects of nintedanib?
The common side effects of nintedanib include diarrhea, nausea, abdominal pain, vomiting, decreased appetite, liver enzyme elevation, fatigue, and weight loss.
3. How should nintedanib be taken?
The recommended dosage of nintedanib is 150 mg twice daily, with food to reduce gastrointestinal side effects.
4. Are there any drug interactions with nintedanib?
Nintedanib may interact with strong CYP3A4 inducers or inhibitors, impacting its plasma concentration. Avoid concomitant use with these agents.
5. What are the contraindications for nintedanib?
Nintedanib is contraindicated in patients with hypersensitivity, severe hepatic impairment, pregnancy, and breastfeeding.
6. Can nintedanib be used during pregnancy?
Nintedanib is not recommended during pregnancy as it may harm the fetus. Consult your healthcare provider for alternative options.
7. How does nintedanib work in the body?
Nintedanib works by inhibiting multiple tyrosine kinases involved in fibrotic disorders, reducing fibroblast proliferation and collagen synthesis.
8. Is nintedanib safe for long-term use?
Your healthcare provider will assess the risks and benefits of long-term nintedanib use. Regular monitoring and follow-up are essential to manage any potential side effects.
