Name: NINTEDANIB 100 MG
Description: Nintedanib is a medication used in the treatment of certain types of lung diseases, such as idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease. It belongs to a class of drugs known as tyrosine kinase inhibitors, which work by blocking certain growth factors that are involved in the progression of these diseases.
Active Ingredients:
The active ingredient in Nintedanib is nintedanib esylate.
Pharmacological Properties:
Nintedanib exerts its pharmacological effects by inhibiting multiple tyrosine kinases that are involved in the process of fibrosis and tissue scarring. By blocking these pathways, nintedanib helps to slow down the progression of lung diseases such as idiopathic pulmonary fibrosis.
Indications:
Nintedanib is indicated for the treatment of idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) in patients who have unmet medical needs or who demonstrate disease progression despite standard therapy.
Contraindications:
Nintedanib is contraindicated in patients with a known hypersensitivity to nintedanib or any of the other ingredients in the formulation. It should not be used in patients with severe hepatic impairment, severe renal impairment, or end-stage kidney disease requiring dialysis.
Dosage:
The recommended dosage of nintedanib for the treatment of IPF and SSc-ILD is 150 mg twice daily with food. The tablets should be swallowed whole with a glass of water and not crushed or chewed.
Side Effects:
Common side effects of nintedanib may include gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain. Other side effects may include liver enzyme elevations, decreased appetite, fatigue, and headache. It is important to notify your healthcare provider if you experience any side effects while taking nintedanib.
Drug Interactions:
Nintedanib may interact with certain medications, such as strong inhibitors or inducers of CYP3A4 and P-glycoprotein. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medicines, and herbal supplements, to avoid potential drug interactions.
Patient Counseling:
Prior to initiating treatment with nintedanib, patients should be counseled on the importance of adherence to the prescribed dosage regimen, the potential side effects of the medication, and the need for regular monitoring of liver function tests. Patients should also be advised to report any new or worsening symptoms to their healthcare provider.
Clinical Evidence:
Several clinical trials have demonstrated the efficacy of nintedanib in slowing down the decline in lung function and reducing the risk of disease progression in patients with IPF and SSc-ILD. Long-term studies have shown that nintedanib can help to improve exercise capacity and quality of life in these patient populations.
Frequently Asked Questions (FAQs):
Q: How long does it take for nintedanib to start working?
A: Nintedanib may start working within a few weeks to months of initiating treatment, although individual responses may vary. It is important to continue taking the medication as prescribed by your healthcare provider to achieve the best possible outcomes.
Q: Can nintedanib cure idiopathic pulmonary fibrosis (IPF) or systemic sclerosis-associated interstitial lung disease (SSc-ILD)?
A: Nintedanib is not a cure for IPF or SSc-ILD, but it can help to slow down the progression of these diseases and improve symptoms in some patients. It is important to follow your treatment plan and attend regular follow-up appointments with your healthcare provider.
Q: Are there any special precautions to take while on nintedanib therapy?
A: Patients taking nintedanib should avoid grapefruit or grapefruit juice, as it may interact with the medication. It is also important to inform other healthcare providers about your nintedanib treatment before undergoing any procedures or starting new medications.
Q: What should I do if I miss a dose of nintedanib?
A: If you miss a dose of nintedanib, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed dose. Contact your healthcare provider if you have any concerns or questions about missed doses.
Q: Can nintedanib be taken during pregnancy or while breastfeeding?
A: Nintedanib may cause harm to an unborn baby, so it is essential to use effective contraception during treatment and avoid becoming pregnant. It is not recommended to breastfeed while taking nintedanib, as it may pass into breast milk and harm the nursing infant. Consult your healthcare provider for further guidance.
Q: How can I access financial assistance programs for nintedanib?
A: Some pharmaceutical companies offer patient assistance programs or co-pay cards to help reduce the cost of nintedanib for eligible patients. You can inquire with your healthcare provider or the medication manufacturer for information on available financial assistance options.
