Introduction:
Kombiglyze XR 5mg/500mg Tablet is a prescription medication used for the management of Type 2 diabetes mellitus. It contains a combination of two active ingredients – Saxagliptin (5mg) and Metformin (500mg). Manufactured by AstraZeneca, each strip of Kombiglyze XR contains 7 extended-release tablets.
Uses:
Kombiglyze XR is primarily indicated for the treatment of Type 2 diabetes mellitus. It helps control blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver.
Price:
The Maximum Retail Price (MRP) of Kombiglyze XR 5mg/500mg Tablet is ₹360.5 per strip.
Dosage:
It is important to take Kombiglyze XR as prescribed by your healthcare provider. The usual dosage is one tablet taken orally with food once a day. Do not chew, crush, or break the tablet, swallow it whole to ensure the extended-release mechanism works effectively.
Benefits:
The benefits of Kombiglyze XR include effective control of blood sugar levels, improved insulin sensitivity, and reduced risk of complications associated with Type 2 diabetes mellitus.
Side Effects:
Some common side effects of Kombiglyze XR may include diarrhea, nausea, vomiting, upset stomach, headache, nasal congestion, sore throat, respiratory tract infections, and hypoglycemia when used in combination with insulin or sulphonylurea.
Active Ingredients:
Kombiglyze XR contains two active ingredients:
– Saxagliptin (5mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor that helps regulate blood sugar levels.
– Metformin (500mg): A biguanide that improves insulin sensitivity and reduces glucose production in the liver.
Pharmacological Properties:
The combined action of Saxagliptin and Metformin in Kombiglyze XR helps lower blood sugar levels by targeting different pathways involved in glucose metabolism. Saxagliptin improves insulin secretion and reduces glucagon levels, while Metformin decreases hepatic glucose production and increases insulin sensitivity in peripheral tissues.
Indications:
Kombiglyze XR is indicated for the management of Type 2 diabetes mellitus in adults. It is typically prescribed when lifestyle modifications such as diet and exercise alone are insufficient to control blood sugar levels.
Contraindications:
Kombiglyze XR is contraindicated in individuals with a known hypersensitivity to Saxagliptin, Metformin, or any other components of the tablet. It should also be avoided in patients with severe renal impairment, hepatic disease, or a history of lactic acidosis.
Drug Interactions:
It is important to inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements. Some drugs may interact with Kombiglyze XR, altering its effectiveness or increasing the risk of side effects. Common interactions include certain diuretics, corticosteroids, and thyroid medications.
Patient Counseling:
Patient counseling is crucial when using Kombiglyze XR. Patients should be advised to take the medication exactly as prescribed, follow a healthy diet and exercise regimen, monitor blood sugar levels regularly, and report any unusual symptoms or side effects to their healthcare provider.
Clinical Evidence:
Clinical studies have shown the effectiveness of Kombiglyze XR in improving glycemic control and reducing hemoglobin A1c levels in patients with Type 2 diabetes mellitus. The combination of Saxagliptin and Metformin has been found to be well-tolerated with a low risk of hypoglycemia.
Frequently Asked Questions:
1. How should I take Kombiglyze XR?
Take Kombiglyze XR exactly as prescribed by your doctor. Swallow the tablet whole with food and do not crush or chew it.
2. What are the common side effects of Kombiglyze XR?
Common side effects may include diarrhea, nausea, vomiting, headache, and hypoglycemia when used in combination with insulin or sulphonylurea.
3. Can Kombiglyze XR be used in combination with other diabetes medications?
It is essential to consult your healthcare provider before combining Kombiglyze XR with other diabetes medications to avoid potential drug interactions and adverse effects.
4. How long does it take for Kombiglyze XR to show its effects?
The onset of action of Kombiglyze XR may vary from individual to individual. It is important to monitor your blood sugar levels regularly and follow up with your doctor as advised.
5. Is Kombiglyze XR habit-forming?
No, Kombiglyze XR is not habit-forming. It is a prescription medication meant for the management of Type 2 diabetes mellitus.
6. What should I do if I miss a dose of Kombiglyze XR?
If you miss a dose of Kombiglyze XR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
For more detailed information and personalized guidance on using Kombiglyze XR, consult your healthcare provider or pharmacist.
MRP:
₹360.5
Manufacturer:
AstraZeneca
Salt:
Saxagliptin (5mg) + Metformin (500mg),
How to UseKombiglyze XR 5mg/500mg Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kombiglyze XR 5mg/500mg Tablet is to be taken with food.
Side Effects of Kombiglyze XR 5mg/500mg Tablet:
Diarrhea,Nausea,Vomiting,Upset stomach,Headache,Nasal congestion (stuffy nose),Sore throat,Respiratory tract infection,Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea,
Alternate Medicines for Kombiglyze XR 5mg/500mg Tablet:
Prescription Required Status:
Prescription Required
Type of Selection:
7 tablet xr in 1 strip
Chemical Class:
Not Listed
Habit Forming:
No
Therapeutic Class:
ANTI DIABETIC
Action Class:
Not Listed
. Please note, this information is for educational purposes only and not intended as medical advice.
