ITRACONAZOLE 400 MG SR: Overview
Itraconazole 400 mg SR is an antifungal medication manufactured by Leeford. It belongs to the category of antifungal medicines and is commonly used in the treatment of fungal infections. Each strip contains 4 tablets of Itraconazole 400 mg SR.
Active Ingredient
The active ingredient in Itraconazole 400 mg SR is itraconazole. It is a triazole antifungal agent that works by inhibiting the growth of fungi. Itraconazole is effective against a wide range of fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis.
Pharmacological Properties
Itraconazole exerts its antifungal effects by interfering with the synthesis of ergosterol, a vital component of the fungal cell membrane. This disruption leads to increased permeability and leakage of cellular contents, ultimately resulting in fungal cell death. Itraconazole is well-absorbed orally and reaches therapeutic concentrations in various tissues, including the skin, nails, and mucous membranes.
Indications
Itraconazole 400 mg SR is indicated for the treatment of various fungal infections, including:
– Invasive aspergillosis
– Histoplasmosis
– Blastomycosis
– Onychomycosis
– Candidiasis
– Dermatophytoses
Contraindications
Itraconazole 400 mg SR is contraindicated in individuals with known hypersensitivity to itraconazole or any of its components. It should not be used in patients with pre-existing liver disease or in those taking certain medications that may interact with itraconazole.
Dosage
The dosage of Itraconazole 400 mg SR may vary depending on the type and severity of the fungal infection being treated. It is essential to follow the prescribing healthcare provider’s instructions and adhere to the recommended dosing schedule. Generally, the recommended dose for most indications is 200-400 mg once daily.
Side Effects
Like all medications, Itraconazole 400 mg SR may cause side effects in some individuals. Common side effects include:
– Nausea
– Vomiting
– Abdominal pain
– Headache
– Dizziness
– Rash
– Liver function abnormalities
It is important to seek medical attention if any serious side effects such as severe allergic reactions, liver problems, or changes in heart rhythm occur.
Drug Interactions
Itraconazole 400 mg SR can interact with several medications, potentially affecting their efficacy or increasing the risk of side effects. Drug interactions may occur with:
– Certain antiviral medications
– Statins
– Antiarrhythmics
– Anticoagulants
It is crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Itraconazole therapy.
Patient Counseling
Patients taking Itraconazole 400 mg SR should be counseled on the following points:
– Take the medication exactly as prescribed and complete the full course of treatment.
– Inform your healthcare provider about any pre-existing medical conditions or allergies.
– Report any side effects or signs of worsening infection promptly.
– Avoid alcohol consumption while taking Itraconazole.
Clinical Evidence
Clinical studies have demonstrated the efficacy of Itraconazole in the treatment of various fungal infections. The medication has been shown to be effective in both superficial and systemic fungal infections, with a favorable safety profile when used appropriately.
Frequently Asked Questions (FAQs)
1. Can I take Itraconazole with food?
Yes, Itraconazole can be taken with food to help improve its absorption. However, some high-fat meals may delay its absorption, so it is best to follow your healthcare provider’s instructions.
2. How long does it take for Itraconazole to start working?
The onset of action of Itraconazole may vary depending on the type of fungal infection being treated. Improvement in symptoms may be noticed within the first few days to weeks of starting treatment.
3. Is it safe to use Itraconazole during pregnancy?
Itraconazole is not recommended during pregnancy, especially during the first trimester, due to potential risks to the fetus. Pregnant women should consult their healthcare provider before using this medication.
4. Can I drink grapefruit juice while taking Itraconazole?
Grapefruit juice may interact with Itraconazole and increase the risk of side effects. It is advisable to avoid consuming grapefruit or grapefruit juice while on Itraconazole therapy.
5. What should I do if I miss a dose of Itraconazole?
If you miss a dose of Itraconazole, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
By adding more detailed information and frequently asked questions about Itraconazole 400 mg SR, patients will have a better understanding of the medication and its use. This expanded content aims to provide comprehensive information for individuals seeking to learn more about this antifungal medication.
