GLIMEPIRIDE + METFORMIN HYDROCHLORIDE: A Comprehensive Guide
Glimepiride 4 mg + Metformin Hydrochloride 1000 mg PR is a combination medication commonly prescribed for the management of type 2 diabetes mellitus. This medicine is manufactured by Life Max Cancer and belongs to the Uncategorised category. Each strip contains 10 tablets with an actual MRP of Rs. 130, but it is available at a discounted price of 67, offering a discount of 48.46%.
Active Ingredients:
The active ingredients in Glimepiride + Metformin Hydrochloride include Glimepiride and Metformin Hydrochloride. Glimepiride is a sulfonylurea that helps lower blood sugar levels by stimulating the release of insulin from the pancreas. Metformin Hydrochloride is a biguanide that improves insulin sensitivity and reduces glucose production in the liver.
Pharmacological Properties:
Glimepiride + Metformin Hydrochloride works through complementary mechanisms to regulate blood sugar levels in patients with type 2 diabetes. Glimepiride stimulates insulin secretion, while Metformin reduces insulin resistance and hepatic glucose production. This combination helps improve glycemic control and lowers hemoglobin A1c levels.
Indications:
Glimepiride + Metformin Hydrochloride is indicated for the treatment of type 2 diabetes mellitus in adults who require dual therapy to achieve glucose control. It is typically prescribed when diet and exercise alone are insufficient to manage blood sugar levels.
Contraindications:
– Hypersensitivity to sulfonylureas or biguanides
– Type 1 diabetes
– Diabetic ketoacidosis
– Severe renal impairment
– Severe hepatic impairment
– Pregnancy and lactation
Dosage:
The usual recommended dose of Glimepiride 4 mg + Metformin Hydrochloride 1000 mg PR is one tablet taken orally once daily with meals. Dosage may vary based on individual patient needs and response to treatment. It is important to follow the dosage instructions provided by your healthcare provider.
Side Effects:
Common side effects of Glimepiride + Metformin Hydrochloride may include:
– Hypoglycemia
– Nausea
– Diarrhea
– Abdominal discomfort
– Headache
Severe side effects may include:
– Lactic acidosis
– Hypersensitivity reactions
– Hepatotoxicity
Drug Interactions:
Glimepiride + Metformin Hydrochloride may interact with other medications, including:
– NSAIDs
– Diuretics
– Beta-blockers
– Corticosteroids
– Antidiabetic agents
It is important to inform your healthcare provider about all the medications you are taking to prevent potential drug interactions.
Patient Counseling:
Patients using Glimepiride + Metformin Hydrochloride should be advised to:
– Take the medication with meals to reduce gastrointestinal side effects
– Monitor blood sugar levels regularly
– Be aware of the symptoms of hypoglycemia and how to manage it
– Inform healthcare providers about any changes in health status or medications
Clinical Evidence:
Several clinical studies have demonstrated the efficacy and safety of Glimepiride + Metformin Hydrochloride in improving glycemic control and reducing HbA1c levels in patients with type 2 diabetes. Consult with your healthcare provider for more information on the clinical evidence supporting this combination therapy.
Frequently Asked Questions (FAQs):
Q: How does Glimepiride + Metformin Hydrochloride work?
A: Glimepiride stimulates insulin release, while Metformin reduces insulin resistance and glucose production in the liver, helping to lower blood sugar levels.
Q: What are the common side effects of this medication?
A: Common side effects may include hypoglycemia, nausea, diarrhea, abdominal discomfort, and headache.
Q: Can Glimepiride + Metformin Hydrochloride be used in type 1 diabetes?
A: No, this medication is contraindicated in patients with type 1 diabetes.
Q: How should Glimepiride + Metformin Hydrochloride be taken?
A: The usual dose is one tablet taken orally once daily with meals, as directed by your healthcare provider.
Q: Is it safe to use Glimepiride + Metformin Hydrochloride during pregnancy?
A: It is not recommended to use this medication during pregnancy. Consult with your healthcare provider for alternative treatment options.
This detailed guide provides essential information about Glimepiride + Metformin Hydrochloride, including its active ingredients, pharmacological properties, indications, contraindications, dosage, side effects, drug interactions, patient counseling, and clinical evidence. Consult with your healthcare provider for personalized advice regarding the use of this medication.
