GLIMEPIRIDE 2 MG + METFORMIN HCL 500 MG SR
Manufacturer: BAJAJ FORMULATIONS
Category: Uncategorised
Packing Type: STRIP of 10TAB
Actual MRP: Rs. 95
Discounted Price: Rs. 30
Discount Percentage: 68.42%
Active Ingredients:
Glimepiride and Metformin HCl are the active ingredients in this medication. Glimepiride is a sulfonylurea used to treat type 2 diabetes by stimulating the release of insulin from the pancreas. Metformin HCl is a biguanide that helps control blood sugar levels by decreasing glucose production in the liver and improving insulin sensitivity.
Pharmacological Properties:
Glimepiride works by increasing insulin secretion from the pancreas, leading to a decrease in blood glucose levels. Metformin HCl works by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues, resulting in improved glucose utilization.
Indications:
Glimepiride + Metformin HCl SR is indicated for the treatment of type 2 diabetes mellitus when diet and exercise alone are not sufficient to control blood sugar levels. It helps lower blood sugar levels and improves glycemic control.
Contraindications:
This medication is contraindicated in patients with a known hypersensitivity to glimepiride, metformin, or any other component of the formulation. It should not be used in individuals with severe kidney or liver impairment, metabolic acidosis, or diabetic ketoacidosis.
Dosage:
The typical starting dose of Glimepiride 2 mg + Metformin HCl 500 mg SR is one tablet taken once daily with a meal to reduce the risk of gastrointestinal side effects. The dosage may be adjusted based on individual response and blood glucose monitoring.
Side Effects:
Common side effects of Glimepiride + Metformin HCl SR include nausea, vomiting, diarrhea, abdominal discomfort, headache, dizziness, and hypoglycemia. Rare but serious side effects may include lactic acidosis, allergic reactions, and liver dysfunction.
Drug Interactions:
This medication may interact with certain drugs such as NSAIDs, ACE inhibitors, beta-blockers, and other antidiabetic agents, leading to potential changes in efficacy or safety. It is important to consult a healthcare provider before starting any new medications with Glimepiride + Metformin HCl SR.
Patient Counseling:
Patients should be counseled on the importance of adherence to the prescribed dosage regimen, regular monitoring of blood glucose levels, and the need for lifestyle modifications including diet and exercise. They should be educated on the signs and symptoms of hypoglycemia and advised on appropriate actions to take if hypoglycemia occurs.
Clinical Evidence:
Clinical studies have demonstrated the efficacy and safety of Glimepiride + Metformin HCl SR in improving glycemic control and reducing HbA1c levels in patients with type 2 diabetes. Long-term data have shown the potential benefits of this combination therapy in reducing the risk of diabetes-related complications.
Frequently Asked Questions (FAQs)
Q: How should I take Glimepiride + Metformin HCl SR?
A: Take one tablet daily with a meal, as directed by your healthcare provider. Do not exceed the recommended dosage without consulting your doctor.
Q: What should I do if I miss a dose?
A: If you miss a dose of Glimepiride + Metformin HCl SR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed dose.
Q: Are there any dietary restrictions while taking this medication?
A: It is important to follow a healthy diet as recommended by your healthcare provider while taking Glimepiride + Metformin HCl SR. Avoid excessive alcohol consumption and high-carbohydrate meals that may affect blood sugar control.
Q: What are the potential side effects of Glimepiride + Metformin HCl SR?
A: Common side effects may include nausea, vomiting, diarrhea, and headache. Serious side effects such as lactic acidosis or hypoglycemia may occur in rare cases. Consult your doctor if you experience any unusual symptoms.
Q: Can Glimepiride + Metformin HCl SR be used during pregnancy?
A: This medication should be used with caution during pregnancy, as it may affect fetal development. Consult your doctor before using Glimepiride + Metformin HCl SR if you are pregnant or planning to become pregnant.
Q: Is it safe to drive or operate machinery while taking this medication?
A: Glimepiride + Metformin HCl SR may cause dizziness or drowsiness in some individuals. It is advised to avoid driving or operating heavy machinery until you know how this medication affects you.
Q: Can I stop taking Glimepiride + Metformin HCl SR if my blood sugar levels are well-controlled?
A: It is important not to discontinue this medication without consulting your healthcare provider, even if your blood sugar levels are stable. Sudden discontinuation may lead to a rebound increase in blood glucose levels.
Q: How does Glimepiride + Metformin HCl SR work in the body?
A: Glimepiride stimulates insulin release from the pancreas, while Metformin decreases glucose production in the liver and improves insulin sensitivity in peripheral tissues. This combination helps lower blood sugar levels by multiple mechanisms.
Overall, Glimepiride + Metformin HCl SR is an effective combination medication for managing type 2 diabetes mellitus. It is important to follow the prescribed dosage and guidance of your healthcare provider to achieve optimal treatment outcomes while minimizing the risk of side effects and drug interactions.
