DABIGATRAN ETEXILATE MESYLATE 110 MG
Description: Dabigatran etexilate mesylate 110 mg is a medication used to prevent blood clots and reduce the risk of stroke in patients with certain heart conditions. It belongs to a class of drugs known as direct thrombin inhibitors.
Manufacturer: United Bioceuticals
Category: Uncategorised
Packing Type: Strip of 10 capsules
Actual MRP: Rs. 245
Discounted Price: Rs. 157
Discount: 35.92%
Active Ingredients:
The active ingredient in Dabigatran etexilate mesylate is dabigatran, which is the prodrug form of dabigatran etexilate. It is a reversible direct thrombin inhibitor.
Pharmacological Properties:
Dabigatran works by inhibiting thrombin, an enzyme responsible for blood clotting. It prevents the conversion of fibrinogen to fibrin, thereby reducing the formation of blood clots. This mechanism of action makes dabigatran effective in preventing strokes and systemic embolism in patients with atrial fibrillation.
Indications:
Dabigatran etexilate mesylate is indicated for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. It is also used for the treatment and prevention of deep vein thrombosis and pulmonary embolism.
Contraindications:
Dabigatran should not be used in patients with active pathological bleeding, severe renal impairment, or a history of hypersensitivity to the drug. It is contraindicated in patients with prosthetic heart valves.
Dosage:
The usual dose of Dabigatran etexilate mesylate is 110 mg taken orally twice daily. The dosage may be adjusted based on individual patient characteristics, such as renal function and risk factors for bleeding.
Side Effects:
Common side effects of Dabigatran include gastrointestinal symptoms such as dyspepsia, gastritis, and abdominal pain. It may also increase the risk of bleeding and bruising. In rare cases, dabigatran can cause severe bleeding events or allergic reactions.
Drug Interactions:
Dabigatran can interact with certain medications, including other anticoagulants, antiplatelet drugs, and drugs that affect kidney function. It is important to consult a healthcare provider before starting any new medications while taking dabigatran.
Patient Counseling:
Patients taking Dabigatran should be counseled on the importance of adherence to the prescribed dosing regimen. They should also be educated on signs of bleeding and when to seek medical attention. It is recommended to keep regular follow-up appointments with a healthcare provider.
Clinical Evidence:
Several clinical studies have demonstrated the efficacy and safety of dabigatran in the prevention of stroke and systemic embolism in patients with atrial fibrillation. It has been shown to be non-inferior or superior to warfarin in terms of effectiveness with a lower risk of intracranial bleeding.
Frequently Asked Questions (FAQs):
1. Can Dabigatran be used in patients with prosthetic heart valves?
No, Dabigatran is contraindicated in patients with prosthetic heart valves due to an increased risk of thromboembolic events.
2. What should I do if I miss a dose of Dabigatran?
If you miss a dose of Dabigatran, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.
3. How long should I take Dabigatran for stroke prevention?
The duration of treatment with Dabigatran for stroke prevention in patients with atrial fibrillation is typically long-term. Your healthcare provider will determine the appropriate duration based on your individual risk factors.
4. Can I take over-the-counter pain relievers like ibuprofen while on Dabigatran?
It is advisable to avoid nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen while taking Dabigatran, as they may increase the risk of bleeding.
5. What should I do in case of bleeding while on Dabigatran?
If you experience unusual bleeding or bruising while taking Dabigatran, seek immediate medical attention. It is important to inform healthcare providers about your use of anticoagulant medications.
This expanded content provides comprehensive information on Dabigatran etexilate mesylate, including its active ingredients, pharmacological properties, indications, contraindications, dosage, side effects, drug interactions, patient counseling, and clinical evidence. The addition of detailed FAQs addresses common queries that patients may have about the medication.
