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Introduction to Azelnidipine 16mg

Azelnidipine 16mg is a medication produced by the manufacturer Pure & Cure. It belongs to the category of Uncategorised medicines and is commonly available in strip packaging with 10 tablets per strip. The actual Maximum Retail Price (MRP) of Azelnidipine 16mg is Rs. 140, but it is currently being offered at a discounted price of Rs. 100, providing a discount of 28.57%.

Active Ingredients

The active ingredient in Azelnidipine 16mg is azelnidipine itself. Azelnidipine is a dihydropyridine calcium channel blocker that works by inhibiting the influx of calcium ions into vascular smooth muscle and myocardium cells. This action leads to vasodilation, reduced peripheral resistance, and decreased blood pressure.

Pharmacological Properties

Azelnidipine exerts its pharmacological effects by selectively blocking L-type calcium channels in the cell membrane of smooth muscle cells. By inhibiting calcium influx, Azelnidipine causes relaxation of vascular smooth muscles, leading to vasodilation. This effect results in a decrease in blood pressure and an improvement in blood flow to various tissues and organs, thereby reducing the workload on the heart.

Indications

Azelnidipine 16mg is indicated for the treatment of hypertension (high blood pressure). It is prescribed to help lower blood pressure and reduce the risk of complications associated with hypertension, such as stroke, heart attack, and kidney problems. Azelnidipine is often used as a first-line treatment for hypertension and can be used alone or in combination with other antihypertensive medications.

Contraindications

Azelnidipine 16mg is contraindicated in individuals with a known hypersensitivity to azelnidipine or any other dihydropyridine calcium channel blockers. It should not be used in patients with severe hypotension, aortic stenosis, acute heart failure, or hepatic impairment. Azelnidipine should also be avoided in pregnant and breastfeeding women unless the benefits outweigh the risks.

Dosage

The usual recommended dose of Azelnidipine for adults is 16mg once daily. The tablets should be taken orally with water, preferably at the same time each day. It is important to follow the dosage instructions provided by your healthcare provider to ensure optimal effectiveness and safety of the medication. Dosage adjustments may be necessary based on individual response and tolerability.

Side Effects

Common side effects of Azelnidipine 16mg may include dizziness, headache, peripheral edema, flushing, and fatigue. These side effects are usually mild and temporary, resolving on their own as the body adjusts to the medication. However, if any side effects persist or worsen, it is important to seek medical advice promptly. Serious side effects such as allergic reactions, chest pain, or irregular heartbeat should be reported immediately to a healthcare professional.

Drug Interactions

Azelnidipine may interact with other medications or substances, potentially affecting its efficacy or safety. It is essential to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Azelnidipine therapy. Drug interactions with Azelnidipine may occur with CYP3A4 inhibitors or inducers, beta-blockers, and other antihypertensive agents. Your doctor will monitor for potential interactions and adjust your treatment plan accordingly.

Patient Counseling

Patients taking Azelnidipine should be advised to take the medication exactly as prescribed by their healthcare provider. It is essential to adhere to the recommended dosage and dosing schedule to achieve optimal blood pressure control. Patients should be educated about the possible side effects of Azelnidipine, how to manage them, and when to seek medical attention. Lifestyle modifications such as a healthy diet, regular exercise, and smoking cessation may complement the effects of Azelnidipine in managing hypertension.

Clinical Evidence

Clinical studies have demonstrated the efficacy and safety of Azelnidipine in lowering blood pressure and managing hypertension. Randomized controlled trials have shown that Azelnidipine is effective in reducing both systolic and diastolic blood pressure levels compared to placebo. Long-term studies have also indicated the cardiovascular protective effects of Azelnidipine in preventing complications associated with hypertension. Overall, Azelnidipine is a valuable antihypertensive medication with a proven track record of effectiveness.

Frequently Asked Questions (FAQs)

Q: Can Azelnidipine be used during pregnancy?

A: Azelnidipine is not recommended for use during pregnancy unless the potential benefits outweigh the risks. Pregnant women should consult with their healthcare provider before taking Azelnidipine.

Q: Is Azelnidipine safe for elderly patients?

A: Azelnidipine can be used in elderly patients with caution and appropriate monitoring. Dose adjustments may be necessary based on individual response and tolerability.

Q: How long does it take for Azelnidipine to lower blood pressure?

A: Azelnidipine may start lowering blood pressure within a few hours of the first dose, but it may take several weeks to achieve optimal blood pressure control. Regular monitoring is essential to assess the effectiveness of Azelnidipine therapy.

Q: Can Azelnidipine cause interactions with other medications?

A: Yes, Azelnidipine may interact with certain medications, such as CYP3A4 inhibitors or inducers, beta-blockers, and other antihypertensive agents. It is important to inform your doctor about all the medications you are taking before starting Azelnidipine.

Q: What should I do if I miss a dose of Azelnidipine?

A: If you miss a dose of Azelnidipine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed dose.

These expanded sections provide comprehensive information about Azelnidipine 16mg, covering its active ingredients, pharmacological properties, indications, contraindications, dosage, side effects, drug interactions, patient counseling, clinical evidence, and frequently asked questions. For any further queries or assistance, feel free to ask!

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