RITUXIMAB 500 MG
Manufacturer: INTAS
Category: Uncategorised
Packing Type: INJECTION of 1 VIAL
Actual MRP: Rs. 41,567
Discounted Price: Rs. 15,665 (Discount: 62.31%)
Active Ingredients:
Rituximab.
Pharmacological Properties:
Rituximab is a monoclonal antibody that targets a specific protein on the surface of immune cells called CD20. By binding to CD20, rituximab helps to destroy these cells, which play a role in various autoimmune diseases and cancers.
Indications:
Rituximab is indicated for the treatment of various conditions, including:
- Non-Hodgkin lymphoma
- Chronic lymphocytic leukemia
- Rheumatoid arthritis
- Granulomatosis with polyangiitis
Contraindications:
Rituximab is contraindicated in individuals with known hypersensitivity to rituximab or any of its components.
Dosage:
The dosage of rituximab may vary depending on the condition being treated. It is typically administered intravenously at a dose of 375 mg/m² body surface area.
Side Effects:
Common side effects of rituximab may include:
- Infusion reactions
- Fatigue
- Fever
- Low white blood cell count
Drug Interactions:
Rituximab may interact with certain medications, including:
- Live vaccines
- Other immunosuppressive agents
- Rituximab is known to suppress the body’s immune system, so caution is advised when using it in combination with other immunosuppressive drugs.
Patient Counseling:
Patients receiving rituximab should be counseled on the following:
- Importance of regular follow-up visits
- Possible side effects and when to seek medical help
- Need for monitoring blood cell counts during treatment
Clinical Evidence:
There is strong clinical evidence supporting the use of rituximab in the treatment of various conditions, with numerous clinical trials demonstrating its efficacy and safety profile.
Frequently Asked Questions:
1. What is the mechanism of action of rituximab?
Rituximab works by targeting and binding to CD20, a protein present on the surface of certain immune cells. This binding triggers the destruction of these cells, leading to the suppression of the immune response.
2. How is rituximab administered?
Rituximab is typically administered intravenously, over the course of several hours in a clinic or hospital setting. The dosage and frequency of administration may vary depending on the condition being treated.
3. What are the common side effects of rituximab?
Common side effects of rituximab include infusion reactions, fatigue, fever, and a decrease in white blood cell count. Patients should report any side effects to their healthcare provider.
4. Can rituximab interact with other medications?
Yes, rituximab can interact with certain medications, especially other immunosuppressive agents. Patients should inform their healthcare provider about all medications they are taking before starting rituximab treatment.
5. How long does rituximab stay in the body?
The half-life of rituximab is approximately 22 days. This means that it takes about 22 days for half of the drug to be eliminated from the body. However, it may take several months for rituximab to be completely cleared from the system.
6. Is rituximab safe for use during pregnancy?
Rituximab is not recommended for use during pregnancy unless the potential benefits outweigh the risks. Pregnant women should discuss the risks and benefits of rituximab treatment with their healthcare provider.
Overall, rituximab is a valuable medication with proven efficacy in treating various conditions. Patients should follow their healthcare provider’s guidance regarding dosing, monitoring, and potential side effects to ensure optimal treatment outcomes.
