Name and Description
The medicine is called Capecitabine 500 mg, manufactured by Biochem. It falls under the Uncategorised category and is packed in a strip of 10 tablets. The actual MRP for this medicine is Rs. 1385.22, but it is currently available at a discounted price of Rs. 550, which represents a discount of 60.30%.
Active Ingredients
Capecitabine contains the active ingredient capecitabine, a chemotherapy medication that is converted into 5-fluorouracil in the body. 5-fluorouracil is an antimetabolite that interferes with the growth of cancer cells.
Pharmacological Properties
Capecitabine is a prodrug that is enzymatically converted to 5-fluorouracil in the body. 5-fluorouracil is a pyrimidine analogue that inhibits thymidylate synthase, an enzyme involved in DNA synthesis. By inhibiting thymidylate synthase, 5-fluorouracil disrupts the production of DNA and RNA, leading to cell death in cancer cells.
Indications
Capecitabine is indicated for the treatment of:
- Colorectal cancer
- Breast cancer
Contraindications
Capecitabine is contraindicated in patients with:
- Known hypersensitivity to capecitabine or 5-fluorouracil
- Severe renal impairment
- Severe hepatic impairment
Dosage
The dosage of capecitabine depends on the type of cancer being treated and other individual factors. It is typically taken orally in the form of tablets and is usually prescribed in cycles.
Side Effects
Common side effects of capecitabine may include:
- Nausea and vomiting
- Diarrhea
- Hand-foot syndrome (palmar-plantar erythrodysesthesia)
- Fatigue
- Stomatitis (inflammation of the mouth)
Drug Interactions
Capecitabine may interact with other medications, so it is essential to inform your healthcare provider about all the drugs you are currently taking. Drug interactions may lead to changes in the effectiveness or side effects of capecitabine.
Patient Counseling
Patient counseling is crucial when using capecitabine. Patients should be educated about the proper dosage, potential side effects, and the importance of adhering to the treatment regimen. It is also essential to discuss any concerns or questions with a healthcare provider.
Clinical Evidence
Several clinical studies have demonstrated the efficacy of capecitabine in the treatment of colorectal and breast cancer. These studies have shown that capecitabine, either alone or in combination with other chemotherapy agents, can improve survival rates and quality of life in patients with these types of cancer.
Frequently Asked Questions
1. Can capecitabine be used for any other types of cancer?
Capecitabine is primarily approved for the treatment of colorectal and breast cancer. However, healthcare providers may sometimes prescribe it off-label for other types of cancer as well.
2. How should capecitabine tablets be taken?
Capecitabine tablets should be taken orally with water. It is essential to follow the dosage and schedule prescribed by your healthcare provider to ensure the medication’s effectiveness.
3. What should I do if I miss a dose of capecitabine?
If you miss a dose of capecitabine, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.
4. Are there any specific dietary restrictions I need to follow while taking capecitabine?
While taking capecitabine, it is advisable to follow a balanced diet rich in nutrients to support your overall health. Avoid consuming grapefruit or grapefruit juice, as it may interact with capecitabine.
5. What should I do if I experience severe side effects while taking capecitabine?
If you experience severe side effects or any signs of an allergic reaction, such as difficulty breathing or swelling of the face, lips, or tongue, seek immediate medical attention. It is essential to report any adverse effects to your healthcare provider.
