**Telmisartan 40mg + Amlodipine 5mg + Hydrochlorothiazide 12.5mg**
**Manufacturer:** Tulbros Formulations
**Category:** Uncategorised
**Packing Type:** Strip of 10 Tablets
**Actual MRP:** Rs. 97
**Discounted Price:** Rs. 52
**Discount:** 46.39%
**Active Ingredients:**
1. **Telmisartan (40mg):** Telmisartan is an angiotensin receptor blocker (ARB) that works by relaxing blood vessels to help lower blood pressure.
2. **Amlodipine (5mg):** Amlodipine is a calcium channel blocker that dilates the blood vessels, improving blood flow.
3. **Hydrochlorothiazide (12.5mg):** Hydrochlorothiazide is a diuretic that helps your body get rid of excess salt and water, thus lowering blood pressure.
**Pharmacological Properties:**
– Telmisartan, a selective angiotensin II receptor antagonist, blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II.
– Amlodipine inhibits calcium ion influx into vascular smooth muscle and cardiac muscle cells, resulting in dilatation of coronary and peripheral arteries.
– Hydrochlorothiazide promotes diuresis by inhibiting the reabsorption of sodium and chloride in the distal renal tubules.
**Indications:**
This combination medication is prescribed for the treatment of hypertension (high blood pressure) in patients who require multiple medications to achieve adequate blood pressure control.
**Contraindications:**
– Hypersensitivity to any of the components
– Pregnancy (particularly during the second and third trimesters)
– Severe renal impairment or anuria
– Severe hepatic impairment
**Dosage:**
The usual recommended starting dose for adults is one tablet once daily, with the dosage adjusted based on individual response to treatment.
**Side Effects:**
Common side effects may include dizziness, headache, edema, flushing, and fatigue. Serious side effects such as severe allergic reactions or liver problems are rare but require immediate medical attention.
**Drug Interactions:**
Certain drugs like potassium supplements, NSAIDs, and lithium may interact with this medication. It is essential to inform your healthcare provider about all the medicines you are taking to avoid potential interactions.
**Patient Counseling:**
Patients should be advised to take the medication as prescribed, monitor their blood pressure regularly, and report any unusual symptoms to their healthcare provider promptly.
**Clinical Evidence:**
Several clinical studies have demonstrated the efficacy and safety of telmisartan, amlodipine, and hydrochlorothiazide combination in managing hypertension and reducing cardiovascular risks.
**Frequently Asked Questions:**
1. **Can I take this medication if I am pregnant?**
– No, this medication is contraindicated during pregnancy, especially in the second and third trimesters.
2. **Is it safe to drive or operate machinery while taking this medicine?**
– This medication may cause dizziness as a side effect, so caution is advised when driving or operating machinery.
3. **Can I drink alcohol while on this medication?**
– It is recommended to limit alcohol consumption as it may increase the risk of side effects such as dizziness.
4. **How long does it take for this medication to start working?**
– Individual response may vary, but patients may start to see improvements in blood pressure within a few weeks of starting treatment.
5. **What should I do if I miss a dose of this medication?**
– If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
In conclusion, Telmisartan 40mg + Amlodipine 5mg + Hydrochlorothiazide 12.5mg is a combination medication used in the management of hypertension, with each component contributing to the overall efficacy of the treatment. Patients should adhere to the prescribed dosage, follow lifestyle recommendations, and report any concerns to their healthcare provider for optimal management of their condition.
