PIOGLITAZONE HCL 15 MG + METFORMIN 500 (SR)
Pioglitazone HCL 15 mg + Metformin 500 (SR) is a combination medication used in the treatment of type 2 diabetes. It contains two active ingredients: pioglitazone hydrochloride and metformin hydrochloride. Pioglitazone is a thiazolidinedione that helps improve insulin sensitivity in the body, while metformin is a biguanide that works by decreasing glucose production in the liver and improving insulin sensitivity in the muscles.
Pharmacological Properties
The pharmacological properties of Pioglitazone HCL and Metformin include their synergy in reducing blood glucose levels in patients with type 2 diabetes. Pioglitazone works by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), which regulates gene expression involved in glucose and lipid metabolism. Metformin, on the other hand, reduces glucose production in the liver and enhances peripheral glucose uptake. The combination of these drugs helps control blood sugar levels effectively.
Indications
Pioglitazone HCL 15 mg + Metformin 500 SR is indicated for the treatment of type 2 diabetes mellitus in adults. It is usually prescribed when diet and exercise alone are not sufficient to control blood sugar levels.
Contraindications
This medication is contraindicated in patients with:
– Severe renal impairment
– Hepatic impairment
– Metabolic acidosis
– Type 1 diabetes or diabetic ketoacidosis
– Allergy to any of the ingredients in the formulation
Dosage
The usual dosage of Pioglitazone HCL 15 mg + Metformin 500 (SR) is one tablet taken orally once or twice daily, as prescribed by a healthcare provider. The dosage may vary depending on the individual’s condition and response to treatment.
Side Effects
Common side effects of Pioglitazone HCL and Metformin may include:
– Nausea
– Diarrhea
– Headache
– Muscle pain
– Weight gain
– Hypoglycemia (low blood sugar)
– Fluid retention
It is important to consult a healthcare provider if any side effects persist or worsen.
Drug Interactions
Pioglitazone HCL 15 mg + Metformin 500 (SR) may interact with other medications such as:
– Insulin or other diabetes medications
– Rifampin
– Cimetidine
– Digoxin
– Furosemide
– Nifedipine
Inform your healthcare provider about all the medications you are taking to avoid potential drug interactions.
Patient Counseling
Patients should be counseled on the following points while taking Pioglitazone HCL and Metformin:
– Take the medication as prescribed by the healthcare provider.
– Follow a healthy diet and exercise regimen to help control blood sugar levels.
– Monitor blood sugar levels regularly as directed.
– Watch for signs of low blood sugar and high blood sugar.
Clinical Evidence
Clinical studies have demonstrated the efficacy of Pioglitazone HCL 15 mg + Metformin 500 (SR) in improving glycemic control in patients with type 2 diabetes. The combination of pioglitazone and metformin has been shown to be effective in reducing HbA1c levels and improving insulin sensitivity.
Frequently Asked Questions (FAQs)
Q: How long does it take for Pioglitazone HCL and Metformin to start working?
A: The onset of action of Pioglitazone HCL and Metformin can vary, but some patients may start to see an improvement in their blood sugar levels within a few weeks of starting the medication.
Q: Can Pioglitazone HCL 15 mg + Metformin 500 (SR) be taken with other diabetes medications?
A: It is important to consult a healthcare provider before taking Pioglitazone HCL and Metformin with other diabetes medications to avoid potential drug interactions.
Q: Are there any specific dietary restrictions while taking Pioglitazone HCL 15 mg + Metformin 500 (SR)?
A: While there are no specific dietary restrictions, it is recommended to follow a healthy diet and avoid excessive intake of sugar and carbohydrates to help control blood sugar levels.
Q: What should I do if I miss a dose of Pioglitazone HCL and Metformin?
A: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Q: Can Pioglitazone HCL 15 mg + Metformin 500 (SR) cause weight gain?
A: Weight gain is a possible side effect of Pioglitazone HCL and Metformin. It is important to monitor your weight regularly and consult with a healthcare provider if you experience significant weight gain.
By providing comprehensive information on Pioglitazone HCL 15 mg + Metformin 500 (SR) and addressing common questions, patients can make informed decisions about their diabetes management.
